First Round
- Buckingham Athletic Dev v Old Bradwell United
- Carterton v Bourton Rovers
- Cheltenham Saracens Res v Newent Town Res
- Chinnor v Thame A
- Clanfield Dev v Long Crendon Res
- Easington Sports Res v Banbury United
- Faringdon Town v Woodstock Town
- Headington Amateurs v Wantage Town
- Highworth Town Res v Shrivenham Dev
- Kidlington Dev v Heyford Athletic
- Kington Town v Malvern Town Dev
- Kintbury Rangers v Eversley & California
- Marlborough Town Dev v Hungerford Swifts
- New Dales Vale v Evesham United Dev
- Penn & Tylers Green Dev v Holmer Green Dev
- SC Inkberrow v Adderbury Park
- Swindon Supermarine Dev v Slimbridge Res
- Taplow United v Newbury
- Tuffley Rovers Dev v Longlevens Dev
ties to be played on Saturday 26th March 2022 with the exception of Chinnor vs Thame A which will take place on the evening of Tuesday 29th March.
The winners of the ties will enter the Challenge Cup, the losers will enter a Supplementary Cup.
