These are the first set of fixtures for 2021/2022 for the Hellenic Premier Divison. Please be aware that these are subject to change over the coming weeks. They are correct as of 21st July 2021.
| Tuesday, 3 August 2021 | Bishops Cleeve | Royal Wootton Bassett |
| Tuesday, 3 August 2021 | Bradford Town | Lydney Town |
| Tuesday, 3 August 2021 | Brimscombe & Thrupp | Longlevens AFC |
| Tuesday, 3 August 2021 | Fairford Town | Chipping Sodbury Town |
| Tuesday, 3 August 2021 | Hallen | Corsham Town |
| Tuesday, 3 August 2021 | Hereford Lads Club | Cribbs |
| Tuesday, 3 August 2021 | Roman Glass St George | Westbury United |
| Tuesday, 3 August 2021 | Shrivenham | Calne Town |
| Tuesday, 3 August 2021 | Tuffley Rovers | Thornbury Town |
| Tuesday, 3 August 2021 | Westfields | Malvern Town |
| Tuesday, 10 August 2021 | Bishops Cleeve | Fairford Town |
| Tuesday, 10 August 2021 | Calne Town | Bradford Town |
| Tuesday, 10 August 2021 | Corsham Town | Thornbury Town |
| Tuesday, 10 August 2021 | Cribbs | Westfields |
| Tuesday, 10 August 2021 | Hallen | Brimscombe & Thrupp |
| Tuesday, 10 August 2021 | Lydney Town | Hereford Lads Club |
| Tuesday, 10 August 2021 | Royal Wootton Bassett | Roman Glass St George |
| Tuesday, 10 August 2021 | Tuffley Rovers | Chipping Sodbury Town |
| Wednesday, 11 August 2021 | Longlevens AFC | Shrivenham |
| Friday, 13 August 2021 | Brimscombe & Thrupp | Calne Town |
| Saturday, 14 August 2021 | Bishops Cleeve | Westbury United |
| Saturday, 14 August 2021 | Bradford Town | Cribbs |
| Saturday, 14 August 2021 | Chipping Sodbury Town | Royal Wootton Bassett |
| Saturday, 14 August 2021 | Hallen | Longlevens AFC |
| Saturday, 14 August 2021 | Hereford Lads Club | Malvern Town |
| Saturday, 14 August 2021 | Shrivenham | Lydney Town |
| Saturday, 14 August 2021 | Thornbury Town | Fairford Town |
| Saturday, 14 August 2021 | Tuffley Rovers | Corsham Town |
| Saturday, 14 August 2021 | Westfields | Roman Glass St George |
| Tuesday, 17 August 2021 | Bishops Cleeve | Thornbury Town |
| Tuesday, 17 August 2021 | Calne Town | Westbury United |
| Tuesday, 17 August 2021 | Chipping Sodbury Town | Hallen |
| Tuesday, 17 August 2021 | Corsham Town | Roman Glass St George |
| Tuesday, 17 August 2021 | Fairford Town | Cribbs |
| Tuesday, 17 August 2021 | Lydney Town | Royal Wootton Bassett |
| Tuesday, 17 August 2021 | Shrivenham | Bradford Town |
| Tuesday, 17 August 2021 | Tuffley Rovers | Malvern Town |
| Wednesday, 18 August 2021 | Brimscombe & Thrupp | Hereford Lads Club |
| Wednesday, 18 August 2021 | Longlevens AFC | Westfields |
| Tuesday, 24 August 2021 | Bishops Cleeve | Roman Glass St George |
| Tuesday, 24 August 2021 | Calne Town | Tuffley Rovers |
| Tuesday, 24 August 2021 | Corsham Town | Lydney Town |
| Tuesday, 24 August 2021 | Cribbs | Thornbury Town |
| Tuesday, 24 August 2021 | Fairford Town | Longlevens AFC |
| Tuesday, 24 August 2021 | Hallen | Hereford Lads Club |
| Tuesday, 24 August 2021 | Royal Wootton Bassett | Brimscombe & Thrupp |
| Tuesday, 24 August 2021 | Westbury United | Shrivenham |
| Saturday, 28 August 2021 | Bishops Cleeve | Lydney Town |
| Saturday, 28 August 2021 | Calne Town | Chipping Sodbury Town |
| Saturday, 28 August 2021 | Corsham Town | Brimscombe & Thrupp |
| Saturday, 28 August 2021 | Cribbs | Roman Glass St George |
| Saturday, 28 August 2021 | Fairford Town | Bradford Town |
| Saturday, 28 August 2021 | Royal Wootton Bassett | Hereford Lads Club |
| Saturday, 28 August 2021 | Thornbury Town | Longlevens AFC |
| Saturday, 28 August 2021 | Tuffley Rovers | Shrivenham |
| Saturday, 28 August 2021 | Westbury United | Westfields |
| Monday, 30 August 2021 | Bishops Cleeve | Malvern Town |
| Monday, 30 August 2021 | Bradford Town | Westbury United |
| Monday, 30 August 2021 | Brimscombe & Thrupp | Fairford Town |
| Monday, 30 August 2021 | Chipping Sodbury Town | Cribbs |
| Monday, 30 August 2021 | Corsham Town | Calne Town |
| Monday, 30 August 2021 | Hallen | Roman Glass St George |
| Monday, 30 August 2021 | Hereford Lads Club | Westfields |
| Monday, 30 August 2021 | Longlevens AFC | Tuffley Rovers |
| Monday, 30 August 2021 | Shrivenham | Royal Wootton Bassett |
| Monday, 30 August 2021 | Thornbury Town | Lydney Town |
| Saturday, 11 September 2021 | Malvern Town | Chipping Sodbury Town |
| Saturday, 11 September 2021 | Westfields | Brimscombe & Thrupp |
| Tuesday, 14 September 2021 | Calne Town | Shrivenham |
| Tuesday, 14 September 2021 | Chipping Sodbury Town | Fairford Town |
| Tuesday, 14 September 2021 | Corsham Town | Hallen |
| Tuesday, 14 September 2021 | Cribbs | Hereford Lads Club |
| Tuesday, 14 September 2021 | Lydney Town | Bradford Town |
| Tuesday, 14 September 2021 | Malvern Town | Westfields |
| Tuesday, 14 September 2021 | Royal Wootton Bassett | Bishops Cleeve |
| Tuesday, 14 September 2021 | Westbury United | Roman Glass St George |
| Wednesday, 15 September 2021 | Longlevens AFC | Brimscombe & Thrupp |
| Saturday, 18 September 2021 | Bishops Cleeve | Cribbs |
| Saturday, 18 September 2021 | Calne Town | Thornbury Town |
| Saturday, 18 September 2021 | Fairford Town | Shrivenham |
| Saturday, 18 September 2021 | Longlevens AFC | Corsham Town |
| Saturday, 18 September 2021 | Lydney Town | Chipping Sodbury Town |
| Saturday, 18 September 2021 | Roman Glass St George | Malvern Town |
| Saturday, 18 September 2021 | Royal Wootton Bassett | Bradford Town |
| Saturday, 18 September 2021 | Tuffley Rovers | Brimscombe & Thrupp |
| Saturday, 18 September 2021 | Westbury United | Hereford Lads Club |
| Saturday, 18 September 2021 | Westfields | Hallen |
| Tuesday, 28 September 2021 | Bradford Town | Calne Town |
| Tuesday, 28 September 2021 | Chipping Sodbury Town | Tuffley Rovers |
| Tuesday, 28 September 2021 | Fairford Town | Bishops Cleeve |
| Tuesday, 28 September 2021 | Hereford Lads Club | Lydney Town |
| Tuesday, 28 September 2021 | Roman Glass St George | Royal Wootton Bassett |
| Tuesday, 28 September 2021 | Shrivenham | Longlevens AFC |
| Tuesday, 28 September 2021 | Thornbury Town | Corsham Town |
| Tuesday, 28 September 2021 | Westfields | Cribbs |
| Wednesday, 29 September 2021 | Brimscombe & Thrupp | Hallen |
| Saturday, 2 October 2021 | Brimscombe & Thrupp | Thornbury Town |
| Saturday, 2 October 2021 | Calne Town | Bishops Cleeve |
| Saturday, 2 October 2021 | Corsham Town | Shrivenham |
| Saturday, 2 October 2021 | Cribbs | Malvern Town |
| Saturday, 2 October 2021 | Fairford Town | Hereford Lads Club |
| Saturday, 2 October 2021 | Hallen | Westbury United |
| Saturday, 2 October 2021 | Longlevens AFC | Chipping Sodbury Town |
| Saturday, 2 October 2021 | Lydney Town | Roman Glass St George |
| Saturday, 2 October 2021 | Royal Wootton Bassett | Westfields |
| Saturday, 2 October 2021 | Tuffley Rovers | Bradford Town |
| Tuesday, 5 October 2021 | Bradford Town | Shrivenham |
| Tuesday, 5 October 2021 | Cribbs | Fairford Town |
| Tuesday, 5 October 2021 | Hallen | Chipping Sodbury Town |
| Tuesday, 5 October 2021 | Hereford Lads Club | Brimscombe & Thrupp |
| Tuesday, 5 October 2021 | Malvern Town | Tuffley Rovers |
| Tuesday, 5 October 2021 | Roman Glass St George | Corsham Town |
| Tuesday, 5 October 2021 | Royal Wootton Bassett | Lydney Town |
| Tuesday, 5 October 2021 | Thornbury Town | Bishops Cleeve |
| Tuesday, 5 October 2021 | Westbury United | Calne Town |
| Tuesday, 5 October 2021 | Westfields | Longlevens AFC |
| Saturday, 9 October 2021 | Brimscombe & Thrupp | Chipping Sodbury Town |
| Saturday, 9 October 2021 | Calne Town | Roman Glass St George |
| Saturday, 9 October 2021 | Corsham Town | Bradford Town |
| Saturday, 9 October 2021 | Cribbs | Hallen |
| Saturday, 9 October 2021 | Fairford Town | Westfields |
| Saturday, 9 October 2021 | Longlevens AFC | Bishops Cleeve |
| Saturday, 9 October 2021 | Malvern Town | Westbury United |
| Saturday, 9 October 2021 | Thornbury Town | Shrivenham |
| Saturday, 9 October 2021 | Tuffley Rovers | Hereford Lads Club |
| Tuesday, 12 October 2021 | Chipping Sodbury Town | Malvern Town |
| Tuesday, 12 October 2021 | Hereford Lads Club | Hallen |
| Tuesday, 12 October 2021 | Lydney Town | Corsham Town |
| Tuesday, 12 October 2021 | Roman Glass St George | Bishops Cleeve |
| Tuesday, 12 October 2021 | Shrivenham | Westbury United |
| Tuesday, 12 October 2021 | Thornbury Town | Cribbs |
| Tuesday, 12 October 2021 | Tuffley Rovers | Calne Town |
| Wednesday, 13 October 2021 | Brimscombe & Thrupp | Royal Wootton Bassett |
| Wednesday, 13 October 2021 | Longlevens AFC | Fairford Town |
| Saturday, 16 October 2021 | Bishops Cleeve | Tuffley Rovers |
| Saturday, 16 October 2021 | Bradford Town | Longlevens AFC |
| Saturday, 16 October 2021 | Chipping Sodbury Town | Corsham Town |
| Saturday, 16 October 2021 | Hallen | Thornbury Town |
| Saturday, 16 October 2021 | Hereford Lads Club | Calne Town |
| Saturday, 16 October 2021 | Malvern Town | Royal Wootton Bassett |
| Saturday, 16 October 2021 | Roman Glass St George | Fairford Town |
| Saturday, 16 October 2021 | Shrivenham | Brimscombe & Thrupp |
| Saturday, 16 October 2021 | Westbury United | Cribbs |
| Saturday, 16 October 2021 | Westfields | Lydney Town |
| Saturday, 23 October 2021 | Bishops Cleeve | Corsham Town |
| Saturday, 23 October 2021 | Chipping Sodbury Town | Thornbury Town |
| Saturday, 23 October 2021 | Cribbs | Royal Wootton Bassett |
| Saturday, 23 October 2021 | Hallen | Shrivenham |
| Saturday, 23 October 2021 | Hereford Lads Club | Longlevens AFC |
| Saturday, 23 October 2021 | Malvern Town | Fairford Town |
| Saturday, 23 October 2021 | Roman Glass St George | Tuffley Rovers |
| Saturday, 23 October 2021 | Westbury United | Lydney Town |
| Saturday, 23 October 2021 | Westfields | Calne Town |
| Tuesday, 26 October 2021 | Bradford Town | Brimscombe & Thrupp |
| Tuesday, 26 October 2021 | Lydney Town | Malvern Town |
| Tuesday, 26 October 2021 | Royal Wootton Bassett | Westbury United |
| Saturday, 30 October 2021 | Brimscombe & Thrupp | Roman Glass St George |
| Saturday, 30 October 2021 | Calne Town | Cribbs |
| Saturday, 30 October 2021 | Chipping Sodbury Town | Bradford Town |
| Saturday, 30 October 2021 | Corsham Town | Westfields |
| Saturday, 30 October 2021 | Fairford Town | Royal Wootton Bassett |
| Saturday, 30 October 2021 | Longlevens AFC | Malvern Town |
| Saturday, 30 October 2021 | Hallen | Lydney Town |
| Saturday, 30 October 2021 | Shrivenham | Bishops Cleeve |
| Saturday, 30 October 2021 | Hereford Lads Club | Thornbury Town |
| Saturday, 30 October 2021 | Tuffley Rovers | Westbury United |
| Saturday, 6 November 2021 | Bradford Town | Westfields |
| Saturday, 6 November 2021 | Brimscombe & Thrupp | Bishops Cleeve |
| Saturday, 6 November 2021 | Calne Town | Malvern Town |
| Saturday, 6 November 2021 | Corsham Town | Hereford Lads Club |
| Saturday, 6 November 2021 | Lydney Town | Cribbs |
| Saturday, 6 November 2021 | Roman Glass St George | Longlevens AFC |
| Saturday, 6 November 2021 | Royal Wootton Bassett | Hallen |
| Saturday, 6 November 2021 | Shrivenham | Chipping Sodbury Town |
| Saturday, 6 November 2021 | Thornbury Town | Tuffley Rovers |
| Saturday, 6 November 2021 | Westbury United | Fairford Town |
| Saturday, 13 November 2021 | Bradford Town | Bishops Cleeve |
| Saturday, 13 November 2021 | Brimscombe & Thrupp | Malvern Town |
| Saturday, 13 November 2021 | Calne Town | Lydney Town |
| Saturday, 13 November 2021 | Chipping Sodbury Town | Hereford Lads Club |
| Saturday, 13 November 2021 | Corsham Town | Westbury United |
| Saturday, 13 November 2021 | Fairford Town | Hallen |
| Saturday, 13 November 2021 | Longlevens AFC | Cribbs |
| Saturday, 13 November 2021 | Shrivenham | Roman Glass St George |
| Saturday, 13 November 2021 | Thornbury Town | Westfields |
| Saturday, 13 November 2021 | Tuffley Rovers | Royal Wootton Bassett |
| Saturday, 20 November 2021 | Bishops Cleeve | Chipping Sodbury Town |
| Saturday, 20 November 2021 | Cribbs | Tuffley Rovers |
| Saturday, 20 November 2021 | Hallen | Bradford Town |
| Saturday, 20 November 2021 | Hereford Lads Club | Shrivenham |
| Saturday, 20 November 2021 | Lydney Town | Fairford Town |
| Saturday, 20 November 2021 | Roman Glass St George | Thornbury Town |
| Saturday, 20 November 2021 | Royal Wootton Bassett | Calne Town |
| Saturday, 20 November 2021 | Westbury United | Longlevens AFC |
| Saturday, 20 November 2021 | Malvern Town | Corsham Town |
| Saturday, 27 November 2021 | Bishops Cleeve | Hereford Lads Club |
| Saturday, 27 November 2021 | Bradford Town | Roman Glass St George |
| Saturday, 27 November 2021 | Brimscombe & Thrupp | Cribbs |
| Saturday, 27 November 2021 | Calne Town | Hallen |
| Saturday, 27 November 2021 | Chipping Sodbury Town | Westfields |
| Saturday, 27 November 2021 | Corsham Town | Royal Wootton Bassett |
| Saturday, 27 November 2021 | Longlevens AFC | Lydney Town |
| Saturday, 27 November 2021 | Shrivenham | Malvern Town |
| Saturday, 27 November 2021 | Thornbury Town | Westbury United |
| Saturday, 27 November 2021 | Tuffley Rovers | Fairford Town |
| Saturday, 4 December 2021 | Cribbs | Corsham Town |
| Saturday, 4 December 2021 | Fairford Town | Calne Town |
| Saturday, 4 December 2021 | Hallen | Bishops Cleeve |
| Saturday, 4 December 2021 | Hereford Lads Club | Bradford Town |
| Saturday, 4 December 2021 | Lydney Town | Tuffley Rovers |
| Saturday, 4 December 2021 | Malvern Town | Thornbury Town |
| Saturday, 4 December 2021 | Roman Glass St George | Chipping Sodbury Town |
| Saturday, 4 December 2021 | Royal Wootton Bassett | Longlevens AFC |
| Saturday, 4 December 2021 | Westbury United | Brimscombe & Thrupp |
| Saturday, 4 December 2021 | Westfields | Shrivenham |
| Saturday, 11 December 2021 | Shrivenham | Hallen |
| Saturday, 11 December 2021 | Thornbury Town | Chipping Sodbury Town |
| Saturday, 11 December 2021 | Brimscombe & Thrupp | Bradford Town |
| Saturday, 11 December 2021 | Corsham Town | Bishops Cleeve |
| Saturday, 11 December 2021 | Longlevens AFC | Hereford Lads Club |
| Saturday, 11 December 2021 | Tuffley Rovers | Roman Glass St George |
| Saturday, 11 December 2021 | Calne Town | Westfields |
| Saturday, 11 December 2021 | Fairford Town | Malvern Town |
| Saturday, 11 December 2021 | Lydney Town | Westbury United |
| Saturday, 11 December 2021 | Royal Wootton Bassett | Cribbs |
| Saturday, 18 December 2021 | Calne Town | Brimscombe & Thrupp |
| Saturday, 18 December 2021 | Corsham Town | Tuffley Rovers |
| Saturday, 18 December 2021 | Cribbs | Bradford Town |
| Saturday, 18 December 2021 | Fairford Town | Thornbury Town |
| Saturday, 18 December 2021 | Longlevens AFC | Hallen |
| Saturday, 18 December 2021 | Lydney Town | Shrivenham |
| Saturday, 18 December 2021 | Malvern Town | Hereford Lads Club |
| Saturday, 18 December 2021 | Roman Glass St George | Westfields |
| Saturday, 18 December 2021 | Royal Wootton Bassett | Chipping Sodbury Town |
| Saturday, 18 December 2021 | Westbury United | Bishops Cleeve |
| Sunday, 26 December 2021 | Calne Town | Corsham Town |
| Sunday, 26 December 2021 | Cribbs | Chipping Sodbury Town |
| Sunday, 26 December 2021 | Fairford Town | Brimscombe & Thrupp |
| Sunday, 26 December 2021 | Lydney Town | Thornbury Town |
| Sunday, 26 December 2021 | Malvern Town | Bishops Cleeve |
| Sunday, 26 December 2021 | Roman Glass St George | Hallen |
| Sunday, 26 December 2021 | Royal Wootton Bassett | Shrivenham |
| Sunday, 26 December 2021 | Tuffley Rovers | Longlevens AFC |
| Sunday, 26 December 2021 | Westbury United | Bradford Town |
| Sunday, 26 December 2021 | Westfields | Hereford Lads Club |
| Sunday, 2 January 2022 | Bradford Town | Royal Wootton Bassett |
| Sunday, 2 January 2022 | Brimscombe & Thrupp | Tuffley Rovers |
| Sunday, 2 January 2022 | Chipping Sodbury Town | Lydney Town |
| Sunday, 2 January 2022 | Corsham Town | Longlevens AFC |
| Sunday, 2 January 2022 | Cribbs | Bishops Cleeve |
| Sunday, 2 January 2022 | Hallen | Westfields |
| Sunday, 2 January 2022 | Hereford Lads Club | Westbury United |
| Sunday, 2 January 2022 | Malvern Town | Roman Glass St George |
| Sunday, 2 January 2022 | Shrivenham | Fairford Town |
| Sunday, 2 January 2022 | Thornbury Town | Calne Town |
| Saturday, 8 January 2022 | Bradford Town | Fairford Town |
| Saturday, 8 January 2022 | Brimscombe & Thrupp | Corsham Town |
| Saturday, 8 January 2022 | Chipping Sodbury Town | Calne Town |
| Saturday, 8 January 2022 | Hallen | Malvern Town |
| Saturday, 8 January 2022 | Hereford Lads Club | Royal Wootton Bassett |
| Saturday, 8 January 2022 | Longlevens AFC | Thornbury Town |
| Saturday, 8 January 2022 | Lydney Town | Bishops Cleeve |
| Saturday, 8 January 2022 | Roman Glass St George | Cribbs |
| Saturday, 8 January 2022 | Shrivenham | Tuffley Rovers |
| Saturday, 8 January 2022 | Westfields | Westbury United |
| Saturday, 15 January 2022 | Bishops Cleeve | Calne Town |
| Saturday, 15 January 2022 | Bradford Town | Tuffley Rovers |
| Saturday, 15 January 2022 | Chipping Sodbury Town | Longlevens AFC |
| Saturday, 15 January 2022 | Hereford Lads Club | Fairford Town |
| Saturday, 15 January 2022 | Malvern Town | Cribbs |
| Saturday, 15 January 2022 | Roman Glass St George | Lydney Town |
| Saturday, 15 January 2022 | Shrivenham | Corsham Town |
| Saturday, 15 January 2022 | Thornbury Town | Brimscombe & Thrupp |
| Saturday, 15 January 2022 | Westbury United | Hallen |
| Saturday, 15 January 2022 | Westfields | Royal Wootton Bassett |
| Saturday, 22 January 2022 | Brimscombe & Thrupp | Shrivenham |
| Saturday, 22 January 2022 | Calne Town | Hereford Lads Club |
| Saturday, 22 January 2022 | Corsham Town | Chipping Sodbury Town |
| Saturday, 22 January 2022 | Cribbs | Westbury United |
| Saturday, 22 January 2022 | Fairford Town | Roman Glass St George |
| Saturday, 22 January 2022 | Longlevens AFC | Bradford Town |
| Saturday, 22 January 2022 | Lydney Town | Westfields |
| Saturday, 22 January 2022 | Royal Wootton Bassett | Malvern Town |
| Saturday, 22 January 2022 | Thornbury Town | Hallen |
| Saturday, 22 January 2022 | Tuffley Rovers | Bishops Cleeve |
| Saturday, 29 January 2022 | Bishops Cleeve | Longlevens AFC |
| Saturday, 29 January 2022 | Bradford Town | Corsham Town |
| Saturday, 29 January 2022 | Chipping Sodbury Town | Brimscombe & Thrupp |
| Saturday, 29 January 2022 | Hallen | Cribbs |
| Saturday, 29 January 2022 | Hereford Lads Club | Tuffley Rovers |
| Saturday, 29 January 2022 | Roman Glass St George | Calne Town |
| Saturday, 29 January 2022 | Shrivenham | Thornbury Town |
| Saturday, 29 January 2022 | Westbury United | Malvern Town |
| Saturday, 29 January 2022 | Westfields | Fairford Town |
| Saturday, 5 February 2022 | Bishops Cleeve | Westfields |
| Saturday, 5 February 2022 | Bradford Town | Malvern Town |
| Saturday, 5 February 2022 | Brimscombe & Thrupp | Lydney Town |
| Saturday, 5 February 2022 | Chipping Sodbury Town | Westbury United |
| Saturday, 5 February 2022 | Corsham Town | Fairford Town |
| Saturday, 5 February 2022 | Longlevens AFC | Calne Town |
| Saturday, 5 February 2022 | Roman Glass St George | Hereford Lads Club |
| Saturday, 5 February 2022 | Shrivenham | Cribbs |
| Saturday, 5 February 2022 | Thornbury Town | Royal Wootton Bassett |
| Saturday, 5 February 2022 | Tuffley Rovers | Hallen |
| Saturday, 12 February 2022 | Bishops Cleeve | Brimscombe & Thrupp |
| Saturday, 12 February 2022 | Chipping Sodbury Town | Shrivenham |
| Saturday, 12 February 2022 | Cribbs | Lydney Town |
| Saturday, 12 February 2022 | Fairford Town | Westbury United |
| Saturday, 12 February 2022 | Hallen | Royal Wootton Bassett |
| Saturday, 12 February 2022 | Hereford Lads Club | Corsham Town |
| Saturday, 12 February 2022 | Longlevens AFC | Roman Glass St George |
| Saturday, 12 February 2022 | Malvern Town | Calne Town |
| Saturday, 12 February 2022 | Thornbury Town | Bradford Town |
| Saturday, 12 February 2022 | Westfields | Tuffley Rovers |
| Saturday, 19 February 2022 | Bishops Cleeve | Shrivenham |
| Saturday, 19 February 2022 | Bradford Town | Chipping Sodbury Town |
| Saturday, 19 February 2022 | Cribbs | Calne Town |
| Saturday, 19 February 2022 | Lydney Town | Hallen |
| Saturday, 19 February 2022 | Malvern Town | Longlevens AFC |
| Saturday, 19 February 2022 | Roman Glass St George | Brimscombe & Thrupp |
| Saturday, 19 February 2022 | Royal Wootton Bassett | Fairford Town |
| Saturday, 19 February 2022 | Thornbury Town | Hereford Lads Club |
| Saturday, 19 February 2022 | Westbury United | Tuffley Rovers |
| Saturday, 19 February 2022 | Westfields | Corsham Town |
| Saturday, 26 February 2022 | Bradford Town | Hallen |
| Saturday, 26 February 2022 | Brimscombe & Thrupp | Westfields |
| Saturday, 26 February 2022 | Calne Town | Royal Wootton Bassett |
| Saturday, 26 February 2022 | Chipping Sodbury Town | Bishops Cleeve |
| Saturday, 26 February 2022 | Corsham Town | Malvern Town |
| Saturday, 26 February 2022 | Fairford Town | Lydney Town |
| Saturday, 26 February 2022 | Longlevens AFC | Westbury United |
| Saturday, 26 February 2022 | Shrivenham | Hereford Lads Club |
| Saturday, 26 February 2022 | Thornbury Town | Roman Glass St George |
| Saturday, 26 February 2022 | Tuffley Rovers | Cribbs |
| Saturday, 5 March 2022 | Bishops Cleeve | Bradford Town |
| Saturday, 5 March 2022 | Cribbs | Longlevens AFC |
| Saturday, 5 March 2022 | Hallen | Fairford Town |
| Saturday, 5 March 2022 | Hereford Lads Club | Chipping Sodbury Town |
| Saturday, 5 March 2022 | Lydney Town | Calne Town |
| Saturday, 5 March 2022 | Malvern Town | Brimscombe & Thrupp |
| Saturday, 5 March 2022 | Roman Glass St George | Shrivenham |
| Saturday, 5 March 2022 | Royal Wootton Bassett | Tuffley Rovers |
| Saturday, 5 March 2022 | Westbury United | Corsham Town |
| Saturday, 5 March 2022 | Westfields | Thornbury Town |
| Tuesday, 8 March 2022 | Malvern Town | Lydney Town |
| Tuesday, 8 March 2022 | Westbury United | Royal Wootton Bassett |
| Saturday, 12 March 2022 | Bishops Cleeve | Hallen |
| Saturday, 12 March 2022 | Bradford Town | Hereford Lads Club |
| Saturday, 12 March 2022 | Brimscombe & Thrupp | Westbury United |
| Saturday, 12 March 2022 | Calne Town | Fairford Town |
| Saturday, 12 March 2022 | Chipping Sodbury Town | Roman Glass St George |
| Saturday, 12 March 2022 | Corsham Town | Cribbs |
| Saturday, 12 March 2022 | Longlevens AFC | Royal Wootton Bassett |
| Saturday, 12 March 2022 | Shrivenham | Westfields |
| Saturday, 12 March 2022 | Thornbury Town | Malvern Town |
| Saturday, 12 March 2022 | Tuffley Rovers | Lydney Town |
| Saturday, 19 March 2022 | Cribbs | Brimscombe & Thrupp |
| Saturday, 19 March 2022 | Fairford Town | Tuffley Rovers |
| Saturday, 19 March 2022 | Hallen | Calne Town |
| Saturday, 19 March 2022 | Hereford Lads Club | Bishops Cleeve |
| Saturday, 19 March 2022 | Lydney Town | Longlevens AFC |
| Saturday, 19 March 2022 | Malvern Town | Shrivenham |
| Saturday, 19 March 2022 | Roman Glass St George | Bradford Town |
| Saturday, 19 March 2022 | Royal Wootton Bassett | Corsham Town |
| Saturday, 19 March 2022 | Westbury United | Thornbury Town |
| Saturday, 19 March 2022 | Westfields | Chipping Sodbury Town |
| Saturday, 26 March 2022 | Calne Town | Longlevens AFC |
| Saturday, 26 March 2022 | Cribbs | Shrivenham |
| Saturday, 26 March 2022 | Fairford Town | Corsham Town |
| Saturday, 26 March 2022 | Hallen | Tuffley Rovers |
| Saturday, 26 March 2022 | Hereford Lads Club | Roman Glass St George |
| Saturday, 26 March 2022 | Lydney Town | Brimscombe & Thrupp |
| Saturday, 26 March 2022 | Royal Wootton Bassett | Thornbury Town |
| Saturday, 26 March 2022 | Westbury United | Chipping Sodbury Town |
| Saturday, 26 March 2022 | Westfields | Bishops Cleeve |
